Biology of Blood and Marrow Transplantation
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9th February 2021
IL-8 Levels Early after Bone Marrow Transplant are Associated with Later Complications of Stem Cell Transplantation
Background: The first two weeks after HSCT can be difficult, with mucositis and intestinal injury. Engraftment further complicates the picture, with release of many bioactive molecules, often leading to fevers and clinical instability. Early events after transplant set the stage for later complications such as acute GVHD and transplant associated thrombotic microangiopathy (TA-TMA), likely by inducing widespread endothelial injury and, in some cases, complement activation, causing further endoth